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Evidence Against a Vasopressor Role of ADH in Malignant Doc-Salt Hypertension
| Content Provider | Scilit |
|---|---|
| Author | Filep, J. Frölich, J. C. Fejes-Toth, G. Rigter, B. |
| Copyright Year | 1985 |
| Description | To investigate the possible role of vasopressin (VP) in the maintenance of DOC-salt hypertension the effect of two VP pressor antagonists on mean arterial pressure and the pressor responsiveness to exogenous VP were studied in conscious, freely moving rats with malignant DOC-salt hypertension. Intravenous injections of either 20 micrograms/kg of dP Tyr(Me)AVP or 10 micrograms/kg of d(CH2)5Tyr(Me)AVP had no significant effect on mean arterial pressure and heart rate, although both antagonists almost completely abolished the pressor response to VP. Furthermore, the animals with DOC-salt hypertension exhibited decreased pressor responsiveness to exogenous VP. The present findings strongly suggest that VP is not essential as a pressor hormone for maintaining blood pressure in malignant DOC-salt hypertension. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/10641968509073603 |
| Ending Page | 1470 |
| Page Count | 14 |
| Starting Page | 1457 |
| ISSN | 07300077 |
| DOI | 10.3109/10641968509073603 |
| Journal | Clinical and Experimental Hypertension. Part A: Theory and Practice |
| Issue Number | 10 |
| Volume Number | 7 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1985-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Clinical and Experimental Hypertension. Part A: Theory and Practice Endocrinology and Metabolism Peripheral Vascular Disease Hypertension Evidence Adh Doc Salt Vasopressor Role Malignant Doc |
| Content Type | Text |
| Resource Type | Article |
| Subject | Internal Medicine |
