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Changes in intrinsic functional brain networks following blast-induced mild traumatic brain injury
| Content Provider | Scilit |
|---|---|
| Author | Vakhtin, Andrei A. Calhoun, Vince D. Jung, Rex E. Prestopnik, Jillian L. Taylor, Paul A. Ford, Corey C. |
| Copyright Year | 2013 |
| Description | Objective: Blast-induced mild traumatic brain injuries (mTBI) commonly go undetected by computed tomography and conventional magnetic resonance imaging (MRI). This study was used to investigate functional brain network abnormalities in a group of blast-induced mTBI subjects using independent component analysis (ICA) of resting state functional MRI (fMRI) data. Methods: Twenty-eight resting state networks of 13 veterans who sustained blast-induced mTBI were compared with healthy controls across three fMRI domains: blood oxygenation level-dependent spatial maps, time course spectra and functional connectivity. Results: The mTBI group exhibited hyperactivity in the temporo-parietal junctions and hypoactivity in the left inferior temporal gyrus. Abnormal frequencies in default-mode (DMN), sensorimotor, attentional and frontal networks were detected. In addition, functional connectivity was disrupted in six network pairs: DMN–basal ganglia, attention–sensorimotor, frontal–DMN, attention–sensorimotor, attention–frontal and sensorimotor–sensorimotor. Conclusions: The results suggest white matter disruption across certain attentional networks. Additionally, given their elevated activity relative to controls', the temporo-parietal junctions of blast mTBI subjects may be compensating for diffuse axonal injury in other cortical regions. |
| Related Links | http://europepmc.org/articles/pmc5075489?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075489/pdf https://www.tandfonline.com/doi/pdf/10.3109/02699052.2013.823561 |
| Ending Page | 1310 |
| Page Count | 7 |
| Starting Page | 1304 |
| ISSN | 02699052 |
| e-ISSN | 1362301X |
| DOI | 10.3109/02699052.2013.823561 |
| Journal | Brain Injury |
| Issue Number | 11 |
| Volume Number | 27 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2013-09-10 |
| Access Restriction | Open |
| Subject Keyword | Journal: Brain Injury Rehabilitation Blast Cognition Functional Magnetic Resonance Imaging (fmri) Independent Component Analysis (ica) Mild Traumatic Brain Injury (mtbi) Resting State Networks (rsn) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Developmental and Educational Psychology Neurology (clinical) |
