NDLI: Failure of combined acetylsalicylic acid and dipyridamole to prevent occlusion of aortocoronary venous bypass graft

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Failure of combined acetylsalicylic acid and dipyridamole to prevent occlusion of aortocoronary venous bypass graft

Content Provider	Scilit
Author	Thaulow, Erik Frøysaker, Tor Dale, Jon Vatne, Karleif
Copyright Year	1987
Description	Patients scheduled to receive at least three aortocoronary venous bypass grafts were randomized to active medication or to placebo. The former were given dipyridamole (DP) preoperatively and acetylsalicylic acid (ASA) was added after the operation. For the next 3 months they received DP 75 mg and ASA 325 mg thrice daily. The placebo regimen was identical and the study was conducted with double-blind technique. One patient in each group died. DP-ASA was discontinued in six patients because of gastrointestinal side effects (bleeding peptic ulcer in 2 cases). Angiography after 3 months revealed the patency rate of individual grafts to be 68% in the DP-ASA group and 77% in the placebo group. DP-ASA therefore did not prevent occlusion of aortocoronary venous bypass grafts.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/14017438709106027
Ending Page	220
Page Count	6
Starting Page	215
ISSN	00365580
DOI	10.3109/14017438709106027
Journal	Scandinavian journal of thoracic and cardiovascular surgery
Issue Number	3
Volume Number	21
Language	English
Publisher	Informa UK Limited
Publisher Date	1987-01-01
Access Restriction	Open
Subject Keyword	Journal: Scandinavian Journal of Thoracic and Cardiovascular Surgery Anesthesiology Graft Occlusion Failure Dipyridamole Venous Bypass Aortocoronary Combined Acetylsalicylic Acid
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine

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