NDLI: Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells

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Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells

Content Provider	Scilit
Author	Song, Jianrui Qu, Zengqiang Guo, Xianling Zhao, Qiudong Zhao, Xue Gao, Lu Sun, Kai Shen, Feng Wu, Mengchao Wei, Lixin
Copyright Year	2009
Description	Hypoxia commonly exists in solid tumors. In this adverse condition, adaptive responses including autophagy are usually provoked to promote cell survival. In our study, autophagy, a lysosomal-mediated degradation pathway, is demonstrated a protective way to make hepatocellular carcinoma cells be resistant to chemotherapy under hypoxia. Compared with normoxia, chemotherapeutic agents-induced cell death under hypoxia was significantly decreased, as a result of the reduced apoptosis. However, when autophagy was inhibited by 3-MA or siRNA targeted Beclin 1, this reduction was reversed i.e. chemoresistance was attenuated, which means autophagy mediates the chemoresistance under hypoxia. In conclusion, autophagy decreases hepatoma cells sensitization to chemotherapeutic agents by affecting their apoptotic potential.
Related Links	https://www.tandfonline.com/doi/pdf/10.4161/auto.5.8.9996?needAccess=true
Ending Page	1144
Page Count	14
Starting Page	1131
ISSN	15548627
e-ISSN	15548635
DOI	10.4161/auto.5.8.9996
Journal	Autophagy
Issue Number	8
Volume Number	5
Language	English
Publisher	Informa UK Limited
Publisher Date	2009-11-16
Access Restriction	Open
Subject Keyword	Journal: Autophagy Biochemistry and Molecular Biology Adaptive Cell Death Chemoresistance Autophagy Apoptosis Survival Hypoxia Chemotherapeutic Hepatocellular Carcinoma
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology

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