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LDL cholesterol is associated with systemic vascular resistance and wave reflection in subjects naive to cardiovascular drugs
| Content Provider | Scilit |
|---|---|
| Author | Choudhary, Manoj Kumar Eräranta, Arttu Tikkakoski, Antti J. Koskela, Jenni Hautaniemi, Elina J. Kähönen, Mika Mustonen, Jukka Pörsti, Ilkka |
| Copyright Year | 2018 |
| Description | Background and aim: Low density lipoprotein cholesterol (LDL-C) is a primary risk factor for atherosclerosis, but it is also associated with elevated blood pressure (BP) and future development of hypertension. We examined the relationship between LDL-C and haemodynamic variables in normotensive and never-treated hypertensive subjects. Methods: We recruited 615 volunteers (19–72 years) without lipid-lowering and BP-lowering medication. Supine haemodynamics were recorded using continuous radial pulse wave analysis, whole-body impedance cardiography, and single channel electrocardiogram. The haemodynamic relations of LDL-C were examined using linear regression analyses with age, sex, body mass index (BMI) (or height and weight as appropriate), smoking status, alcohol use, and plasma C-reactive protein, sodium, uric acid, high density lipoprotein cholesterol (HDL-C), triglycerides, estimated glomerular filtration rate, and quantitative insulin sensitivity check index as the other included variables. Results: The mean (SD) characteristics of the subjects were: age 45 (12) years, BMI 27 (4) $kg/m^{2}$, office BP 141/89 (21/13) mmHg, creatinine 74 (14) µmol/l, total cholesterol 5.2 (1.0), LDL-C 3.1 (0.6), triglycerides 1.2 (0.8), and HDL-C 1.6 (0.4) mmol/l. LDL-C was an independent explanatory factor for aortic systolic and diastolic BP, augmentation index, pulse wave velocity (PWV), and systemic vascular resistance index (p < 0.05 for all). When central BP was included in the model for PWV, LDL-C was no longer an explanatory factor for PWV. Conclusions: LDL-C is independently associated with BP via systemic vascular resistance and wave reflection. These results suggest that LDL-C may play a role in the pathogenesis of primary hypertension. |
| Related Links | https://trepo.tuni.fi/bitstream/10024/105212/1/LDL_cholestrol_is_associated_with_2019.pdf |
| ISSN | 08037051 |
| e-ISSN | 16511999 |
| DOI | 10.1080/08037051.2018.1521263 |
| Journal | Blood Pressure |
| Issue Number | 1 |
| Volume Number | 28 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2018-10-29 |
| Access Restriction | Open |
| Subject Keyword | Journal: Blood Pressure Peripheral Vascular Disease Augmentation Index Haemodynamics Hypertension Impedance Cardiography Ldl Cholesterol Pulse Wave Analysis Systemic Vascular Resistance |
| Content Type | Text |
| Resource Type | Article |
| Subject | Internal Medicine Cardiology and Cardiovascular Medicine |
