NDLI: Aspartame-Direct Compression Excipients: Preformulation Stability Screening Using Differential Scanning Calorimetry

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Aspartame-Direct Compression Excipients: Preformulation Stability Screening Using Differential Scanning Calorimetry

Content Provider	Scilit
Author	El-Shattawy, Hamed H. Peck, Garnet E. Kildsig, Dane O.
Copyright Year	1981
Description	Differential scanning calorimetry was used as a screening technique for assessing the compatibility of Aspartame with some of the currently available direct compression excipients. AsDartame was found to be compatible with Avicel PH 101, Avicel PH 105, Elcema F 150, Elcema G 250, Sta-Rx 1500, Cab-O-Sil, Sorbitol, Di-Pac and Brownex Sugar, while incompatible with dicalcium phosphate dihydrate. It appears that stearic acid can be used as a lubricant in formulations containing Aspartame while magnesium stearate cannot.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/03639048109057733
Ending Page	619
Page Count	15
Starting Page	605
ISSN	03639045
e-ISSN	15205762
DOI	10.3109/03639048109057733
Journal	Drug Development and Industrial Pharmacy
Issue Number	5
Volume Number	7
Language	English
Publisher	Informa UK Limited
Publisher Date	1981-01-01
Access Restriction	Open
Subject Keyword	Journal: Drug Development and Industrial Pharmacy Pharmacology and Pharmacy Calorimetry Aspartame Direct Direct Compression Stability Screening Compression Excipients Preformulation Stability
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science

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