NDLI: Applications of Nanoparticles in the Treatment of Gliomas

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Applications of Nanoparticles in the Treatment of Gliomas

Content Provider	Scilit
Author	Caruso, Gerardo Fazzari, Elena Cardali, Salvator M. Caffo, Maria
Copyright Year	2020
Description	Malignant gliomas are the most common primary brain tumors in adults; they include 78% of all primary malignant brain tumors. The efficacy of current multimodal therapeutic strategies in gliomas is limited by the lack of specific therapies against the malignant cells. The prognosis in patients affected by primary brain tumors is still very unfavorable. Late diagnosis and the limitation of conventional therapies, which may result from inefficient delivery of the therapeutic or contrast agent, are major challenges of glioma treatment. The difficulty in overcoming the blood–brain 186barrier is one of the biggest obstacles for the delivery of chemotherapeutics. Nanotechnology-based drugs that can cross the blood–brain barrier and carry drugs or genes targeted against brain tumors could revolutionize the therapy of malignant gliomas. Nanotechnology has quickly found its application in clinical methodologies including imaging, diagnostic, and therapeutics. Nanoparticle systems are versatile and provide prolonged drug delivery directly to the tumor following direct intracerebral injection or by functionalizing the material surface with peptides and ligands allowing the drug-loaded material to be specifically targeted to the tumor. In this chapter, we describe the principal applications of nanomedicine in malignant gliomas and discuss various preclinical and/or clinical studies used to treat these aggressive brain tumors. Book Name: Nanoparticle Drug Delivery Systems for Cancer Treatment
Related Links	https://content.taylorfrancis.com/books/download?dac=C2019-0-05229-X&isbn=9780429341250&doi=10.1201/9780429341250-7&format=pdf
Ending Page	219
Page Count	35
Starting Page	185
DOI	10.1201/9780429341250-7
Language	English
Publisher	Informa UK Limited
Publisher Date	2020-02-19
Access Restriction	Open
Subject Keyword	Book Name: Nanoparticle Drug Delivery Systems for Cancer Treatment Biomedical Engineering Nanoparticles Nanotechnology Efficacy Adults Gliomas Malignant Brain Tumors Functionalizing
Content Type	Text
Resource Type	Chapter

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