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Cerebrospinal fluid T cells from multiple sclerosis patients recognize autologous Epstein-Barr virus-transformed B cells.
| Content Provider | Scilit |
|---|---|
| Author | Holmøy, Trygve Vartdal, Frode |
| Copyright Year | 2004 |
| Description | The association between multiple sclerosis and Epstein-Barr virus infection could involve Epstein-Barr virus-specific T cells, provided that these T cells get access to the intrathecal compartment. We report that $CD4^{+}$ T cells from the cerebrospinal fluid of six out of six multiple sclerosis patients, and four out of six patients with other neurological diseases, recognized autologous B cells transformed with Epstein-Barr virus. The cerebrospinal fluid T-cell responses were predominantly HLA-DR restricted. These T cells did not recognize B cells activated through stimulation of CD40 or the inducible autoantigen αB crystalline. These findings support that the immunological response to Epstein-Barr virus could contribute to the pathogenesis of multiple sclerosis. |
| Related Links | http://link.springer.com/content/pdf/10.1080%2F13550280490261671.pdf |
| Ending Page | 56 |
| Page Count | 5 |
| Starting Page | 52 |
| ISSN | 13550284 |
| e-ISSN | 15382443 |
| DOI | 10.1080/13550280490261671 |
| Journal | Journal of NeuroVirology |
| Issue Number | 1 |
| Volume Number | 10 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2004-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Neurovirology Virology Cerebrospinal Fluid Multiple Sclerosis Epstein-barr Virus T Cells |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Virology Neurology (clinical) Cellular and Molecular Neuroscience |
