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GTP-dependent scaffold formation in the GTPase of Immunity-Associated Protein family
| Content Provider | Scilit |
|---|---|
| Author | Schwefel, David Daumke, Oliver |
| Copyright Year | 2011 |
| Description | GTPases of Immunity-Associated Proteins (GIMAPs) are a family of guanine nucleotide binding (G) proteins which are implicated in the regulation of apoptosis in lymphocytes. GIMAPs are composed of an amino-terminal G domain and carboxy-terminal extensions of varying size. Our recent biochemical and structural analysis of a representative GIMAP family member, GIMAP2, revealed the molecular basis of GTP-dependent oligomerization which involves two interfaces in the G domain. Whereas the amphipathic helix α7 in the C-terminal extension closely folds against the G domain in the GDP-bound state, it might be released in the GTP-bound state to assemble interaction partners. We also showed that the GIMAP2 oligomer functions at the surface of lipid droplets in a Jurkat T cell line. Here, we review our recent work and discuss the GIMAP2 oligomer as a GTP-dependent protein scaffold at the surface of lipid droplets controlling apoptosis. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.4161/sgtp.2.1.14938?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116615/pdf |
| Ending Page | 30 |
| Page Count | 4 |
| Starting Page | 27 |
| ISSN | 21541248 |
| e-ISSN | 21541256 |
| DOI | 10.4161/sgtp.2.1.14938 |
| Journal | Small GTPases |
| Issue Number | 1 |
| Volume Number | 2 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2011-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Small Gtpases Biochemistry and Molecular Biology Gimap Gtpase Protein Scaffold Lipid Droplets Lymphocytes Protein Structure Immunity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry |
