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Autophagy mediated CoCrMo particle-induced peri-implant osteolysis by promoting osteoblast apoptosis
| Content Provider | Scilit |
|---|---|
| Author | Wang, Zhenheng Liu, Naicheng Liu, Kang Zhou, Gang Gan, Jingjing Shi, Tong Guo Zhenheng, Wang Wang, Lintao Tongguo, Shi Bao, Nirong Wang, Rui Huang, Zhen Chen, Jiangning Dong, Lei Zhao, Jianning Zhang, Junfeng |
| Copyright Year | 2015 |
| Description | Wear particle-induced osteolysis is the leading cause of aseptic loosening, which is the most common reason for THA (total hip arthroplasty) failure and revision surgery. Although existing studies suggest that osteoblast apoptosis induced by wear debris is involved in aseptic loosening, the underlying mechanism linking wear particles to osteoblast apoptosis remains almost totally unknown. In the present study, we investigated the effect of autophagy on osteoblast apoptosis induced by CoCrMo metal particles (CoPs) in vitro and in a calvarial resorption animal model. Our study demonstrated that CoPs stimulated autophagy in osteoblasts and PIO (particle-induced osteolysis) animal models. Both autophagy inhibitor 3-MA (3-methyladenine) and siRNA of Atg5 could dramatically reduce CoPs-induced apoptosis in osteoblasts. Further, inhibition of autophagy with 3-MA ameliorated the severity of osteolysis in PIO animal models. Moreover, 3-MA also prevented osteoblast apoptosis in an antiautophagic way when tested in PIO model. Collectively, these results suggest that autophagy plays a key role in CoPs-induced osteolysis and that targeting autophagy-related pathways may represent a potential therapeutic approach for treating particle-induced peri-implant osteolysis. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835204/pdf |
| Ending Page | 2369 |
| Page Count | 12 |
| Starting Page | 2358 |
| ISSN | 15548627 |
| e-ISSN | 15548635 |
| DOI | 10.1080/15548627.2015.1106779 |
| Journal | Autophagy |
| Issue Number | 12 |
| Volume Number | 11 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2015-12-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Autophagy Biomaterials Aseptic Loosening Autophagy Osteoblasts Osteolysis Wear Particles |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology |
