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Altered Disposition of Vascular Catecholamines in Hypertensive (Doca-Salt) Rats
| Content Provider | Scilit |
|---|---|
| Author | Crabb, G. A. Head, R. J. Hempstead, J. Berkowitz, B. A. |
| Copyright Year | 1980 |
| Description | The levels of norepinephrine (NE), dopamine (DA) and epinephrine (E) in the vasculature of hypertension (DOCA-SALT) and normotensive rats were determined by radioenzymatic assay. Significant decreases in the NE content of the mesenteric artery, renal artery and cardiac tissue from DOCA-Salt treated rats were found. In contrast the NE content of the inferior vena cava, abdominal aorta and mesenteric vein were not significantly decreased in the DOCA-Salt treated rats. There was no evidence of an altered disposition of DA and E in the vasculature of DOCA-Salt treated rats. The results of the study indicate that NE is selectively depleted in the cardiovascular system of this model of experimental hypertension and it is proposed that this property reflects different functional roles of individual elements of the vasculature in the DOCA-Salt hypertensive rat. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.3109/10641968009038556 |
| Ending Page | 138 |
| Page Count | 10 |
| Starting Page | 129 |
| ISSN | 01483927 |
| DOI | 10.3109/10641968009038556 |
| Journal | Clinical and experimental hypertension |
| Issue Number | 1 |
| Volume Number | 2 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1980-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Clinical and Experimental Hypertension Peripheral Vascular Disease Rats Doca Salt Hypertension Artery Functional Vasculature Mesenteric |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
