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Semen Characteristics and Serum and Seminal Plasma Hormones in Drug-Induced Hyperprolactinaemia
| Content Provider | Scilit |
|---|---|
| Author | Díez, L. C. García Buitrago, J. M. Gonzalez |
| Copyright Year | 1982 |
| Description | Semen volume, density, motility, viability, and morphology of spermatozoa, and serum and seminal plasma levels of the hormones FSH, LH, prolactin, progesterone, 17-α-hydroxypro-gesterone, androstenedione, testosterone, dihidrotestosterone, and estradiol 17-β have been measured in 22 men subjected to experimental hyperprolactinaemia by the simultaneous administration of the antidopaminergic drugs metoclopramide and sulpiride. Hyperprolactinaemia produces a decrease of semen volume and seminal quality. In hyperprolactinaemia, normozoospermic patients had an increase of serum androstenedione. In both normo- and oligozoospermic groups, a decrease of serum testosterone was observed. Hyperprolactinaemia also causes an inhibition of the secretory activity of the accessory sexual glands of the reproductive tract, as well as either a decrease of 17-ketosteroid reductase or an increase of I7-α-hydroxysteroid dehydrogenase (enzymes that participate in the androstenedione-testosterone inter-conversions). This change appears to be more pronounced in individuals with good seminal quality. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.3109/01485018208990257?needAccess=true http://www.tandfonline.com/doi/pdf/10.3109/01485018208990257 |
| Ending Page | 317 |
| Page Count | 7 |
| Starting Page | 311 |
| ISSN | 01485016 |
| e-ISSN | 15210375 |
| DOI | 10.3109/01485018208990257 |
| Journal | Archives of andrology |
| Issue Number | 4 |
| Volume Number | 9 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1982-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Archives of Andrology Endocrinology and Metabolism Hormone |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology |
