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The ups and downs of p53 regulation in hematopoietic stem cells
| Content Provider | Scilit |
|---|---|
| Author | Abbas, Hussein A. Pant, Vinod Lozano, Guillermina |
| Copyright Year | 2011 |
| Description | Hematopoietic stem cells provide an indispensible source for replenishing the blood with all its constituents throughout the organism's lifetime. Mice with a compromised hematopoietic stem cell compartment cannot survive. p53, a major tumor suppressor gene, has been implicated in regulation of hematopoiesis. In particular, p53 plays a role in homeostasis by regulating HSC quiescence and self renewal. We recently utilized a hypomorphic $p53^{515C}$ allele in conjunction with Mdm2, a negative regulator of p53 to gain insights into the role of p53 in hematopoietic regulation. Our analyses revealed that $p53^{515C/515C}Mdm2^{-/-}$ double mutant mice die soon after birth due to hematopoietic failure. Further mechanistic studies revealed that in the absence of Mdm2, ROS induced postnatal p53 activity depletes hematopoietic stem cells, progenitors and differentiated cells. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.4161/cc.10.19.17721?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233622/pdf |
| Ending Page | 3262 |
| Page Count | 6 |
| Starting Page | 3257 |
| ISSN | 15384101 |
| e-ISSN | 15514005 |
| DOI | 10.4161/cc.10.19.17721 |
| Journal | Cell Cycle |
| Issue Number | 19 |
| Volume Number | 10 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2011-10-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cell Cycle Medical Laboratory Technology Hsc Reactive Oxygen Species Ros P53 Mdm2 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Developmental Biology Medicine Molecular Biology |
