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Introduction to Oral and Craniofacial Tissue Engineering
| Content Provider | Scilit |
|---|---|
| Author | González, María Verónica Cuevas Villarreal-Ramírez, Eduardo Pérez-Soria, Adriana Reynoso, Pedro Alberto López Guarino, Vincenzo Alvarez-Pérez, Marco Antonio |
| Copyright Year | 2020 |
| Description | Book Name: Current Advances in Oral and Craniofacial Tissue Engineering |
| Abstract | Oral and craniofacial tissues are important in several physiological functions such as mastication, speech, facial aesthetics, and the most important in the quality of health in life. In this fundamental role, teeth are essential to these functions relying on its unique combination of hard tissues—including enamel, dentin, root cementum and alveolar bone and soft tissues—including periodontal ligament, gingiva and dental pulp (Orsini et al. 2018 a, b). The development of all organs which form from the ectodermal and endodermal sheets lining the embryo is regulated by the communication between the epithelium and underlying mesenchyme. Teeth are unique, greatly specialized organs, in which studies of classic tissue recombination in the developmental biology field established that the tooth shape, dental cells and tissues, takes place through a strict series of well-defined regulated stages that involve this kind of communication (Luukko and Kettunen 2016). This process in tooth development is characterized by complex reciprocal interactions between the epithelial and mesenchymal tissue, which occur in a stepwise process classically described, from early to late as Lamina, Bud, Cap and Bell stages (early and late stage), in which each phase is discernible by specific histomorphological and cellular features (Yildirim et al. 2011; Mitsiadis and Harada 2015; Thesleff 2014). In recent years, with a better understanding of molecular biology and cell-tissue signaling, the process of tooth development could be broadly described as a sequential differentiation process mediated by the conserved signaling pathways, such as FGF, BMP, Hedgehog, EDA, and Wnt, where the basal cells of the dental lamina (dental epithelial tissue) undergo proliferation and form a horseshoe-shaped band that invaginates into the underlying mesenchymal tissue (this process is called epithelium invagination). The mesenchymal 2tissue, derived from neural crest cells, proliferated and differentiated to ameloblasts for depositing the enamel tissue, meanwhile mesenchymal tissue responds to dental epithelial signaling beginning with the process of differentiation into cementoblasts, periodontal ligament, odontoblasts and other dental pulp cells (including neurons, endothelial cells and fibroblasts) (Caton and Tucker 2009; Balic 2018; Xiao and Nasu 2014). Thus, tooth-specific tissues originating from the two principal sources gives the complete anatomy of soft and hard tissues in teeth, including dentin, dental pulp, alveolar bone and periodontal ligament. |
| Related Links | https://content.taylorfrancis.com/books/download?dac=C2018-0-88667-1&isbn=9780429423055&doi=10.1201/9780429423055-1&format=pdf |
| DOI | 10.1201/9780429423055-1 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2020-08-07 |
| Access Restriction | Open |
| Subject Keyword | Book Name: Current Advances in Oral and Craniofacial Tissue Engineering Dentistry and Oral Surgery Differentiation Soft Tissue Dentin Alveolar Bone Enamel Hard Dental Cells Underlying Mesenchyme |
| Content Type | Text |
| Resource Type | Chapter |
