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Correlation between oocyte morphology and the embryo aneuploidy rate in IVF cycles
| Content Provider | Scilit |
|---|---|
| Author | Dolgushina, Nataliya V. Syrkasheva, Anastasiia G. Makarova, Nataliya P. Kovalskaya, Eugenia V. Kalinina, Elena A. Sukhikh, Gennady T. |
| Copyright Year | 2015 |
| Description | Purpose: To evaluate the aneuploidy rates of 13, 18, and 21 and the X and Y chromosomes in embryos from patients with morphologically normal oocytes and different oocyte dysmorphisms. Methods: This prospective cohort study included 84 patients treated with in vitro fertilization (IVF) at a single academic center. The patients were divided into the following three groups: group 1 – women with cytoplasmic dysmorphisms (n = 28), group 2 – women with extracytoplasmic dysmorphisms (n = 28), and group 3 – women with morphologically normal oocytes (n = 28). One blastomere from each embryo was analyzed for aneuploidies of chromosomes 13, 18, 21, X, and Y. Results: The highest prevalence of aneuploid embryos was observed in the group 1 (68.4%) followed by the group 2 (38.9%) and the group 3 (31.3%) (р < 0.0001). The adjusted OR for receiving an aneuploid embryo in the case of cytoplasmic dysmorphism was 3.6 (95% CI = 1.8; 7.2), in the case of extracytoplasmic dysmorphisms – 1.3 (95% CI = 0.7; 2.1). Conclusions: Women with morphological oocyte abnormalities are at risk for developing aneuploid embryos during IVF cycles. We recommend that woman with cytoplasmic oocyte dysmorphisms receive additional genetic counseling to define the indications for the genetic screening of embryos. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.3109/09513590.2015.1086511 |
| Ending Page | 64 |
| Page Count | 4 |
| Starting Page | 61 |
| ISSN | 09513590 |
| e-ISSN | 14730766 |
| DOI | 10.3109/09513590.2015.1086511 |
| Journal | Gynecological Endocrinology |
| Issue Number | sup1 |
| Volume Number | 31 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2015-10-05 |
| Access Restriction | Open |
| Subject Keyword | Journal: Gynecological Endocrinology Rehabilitation Aneuploidy in Vitro Fertilization Oocyte Dysmorphisms Oocyte Morphology Oocyte Quality Preimplantation Genetic Screening |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Endocrinology Obstetrics and Gynecology |
