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High dose dexamethasone therapy shows better responses in acute immune thrombocytopenia than in chronic immune thrombocytopenia
| Content Provider | Scilit |
|---|---|
| Author | Naithani, Rahul Mahapatra, M. Kumar, Rajat Mishra, Pravas Saxena, Renu |
| Copyright Year | 2010 |
| Description | Oral high dose dexamethasone (HDD) was given as a single daily dose for four consecutive days, every 14 days for four courses. Twenty-nine patients were enrolled. Overall 20 patients (69%) responded: complete response (CR) was achieved in 16 (55%) patients, partial response (PR) in three (10%) patients and MR in one (3%) patient. In acute immune thrombocytopenic purpura (ITP) response rates after the first, second, third and fourth cycles were as follows: 64% (9/14), 64% (9/14), 79% (11/14), and 85.7% (12/14), respectively. In chronic ITP, overall response rates after the first, second, third and fourth cycles were as follows: 33% (5/15), 40% (6/15), 53% (8/15) and 53% (8/15) respectively. The median time to response was 14 days (4-42 days). Twelve out of 20 patients (5/12 acute ITP and 7/8 chronic ITP) relapsed; median relapse free survival till last follow-up in the remaining eight patients was 130 days (65-365 days). |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/09537101003637257 |
| Ending Page | 273 |
| Page Count | 4 |
| Starting Page | 270 |
| ISSN | 09537104 |
| e-ISSN | 13691635 |
| DOI | 10.3109/09537101003637257 |
| Journal | Platelets |
| Issue Number | 4 |
| Volume Number | 21 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2010-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Platelets Hematology Acute Immune Relapse Immune Thrombocytopenia Complete Response Itp High Dose Dexamethasone |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology |
