NDLI: Eosinophil Accumulation and Activation in Antigen-Induced Late Asthmatic Response in Guinea Pigs

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Eosinophil Accumulation and Activation in Antigen-Induced Late Asthmatic Response in Guinea Pigs

Content Provider	Scilit
Author	Sugiyama, Haruhito Eda, Ryosuke Okada, Chiharu Hopp, Russell J. Bewtra, Againdra K. Townley, Robert G.
Copyright Year	1995
Description	The purpose of this study was to investigate the participation of airway eosinophils in the antigen-induced late asthmatic response (LAR) and increased airway responsiveness in the guinea pig model of asthma. After antigen challenge, guinea pigs sensitized with aerosolized ovalbumin showed a late-phase decrease in specific airway conductance, which was accompanied by airway hyperresponsiveness to histamine, eosinophilia in the bronchoalveolar lavage fluid (BALF), decreased BALF eosinophil density, and increased generation of superoxide anions from purified BALF eosinophils. We demonstrated an association of the LAR with eosinophil accumulation and activation in the airway.
Related Links	https://www.tandfonline.com/doi/pdf/10.3109/02770909509089498
Ending Page	45
Page Count	9
Starting Page	37
ISSN	02770903
e-ISSN	15324303
DOI	10.3109/02770909509089498
Journal	Journal of Asthma
Issue Number	1
Volume Number	32
Language	English
Publisher	Informa UK Limited
Publisher Date	1995-01-01
Access Restriction	Open
Subject Keyword	Journal: Journal of Asthma Anesthesiology Model Eosinophils Pigs Airway Antigen Balf Guinea Pig Late Asthmatic
Content Type	Text
Resource Type	Article
Subject	Pulmonary and Respiratory Medicine Immunology and Allergy Pediatrics, Perinatology and Child Health

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