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Sex-specific differences in the salivary microbiome of caries-active children
| Content Provider | Scilit |
|---|---|
| Author | Ortiz, Stephanie Herrman, Elisa Lyashenko, Claudia Purcell, Anne Raslan, Kareem Khor, Brandon Snow, Michael Forsyth, Anna Choi, Dongseok Maier, Tom Machida, Curtis A. |
| Copyright Year | 2019 |
| Description | Background and Objectives: Dental caries is a chronic disease affecting young children and has multi-factorial risk factors. The purpose of this work was to identify sex-specific differences in the salivary microbiota within caries-active children. Design: Saliva specimens were collected from 85 children (boys: 41; girls: 44) between the ages of 2-12 years. Salivary microbial DNA was subjected to PCR amplification using V3-V4 16S rDNA-specific primers and next-generation sequencing. Results: Significant sex differences in salivary microbiota were found between caries-active boys versus caries-active girls. Neisseria flavescens, Rothia aeria, and Haemophilus pittmaniae were found at significantly higher levels in caries-active boys. In contrast, Lactococcus lactis, Selenomonas species HOT 126, Actinobaculum species HOT 183, Veillonella parvula, and Alloprevotella species HOT 473 were found at significantly higher levels in caries-active girls. Conclusion: We have found the acid-generating, cariogenic Lactococcus lactis to be much more abundant in caries-active girls than caries-active boys, indicating that this microorganism may play a more significant role in shaping the cariogenic microbiome in girls. In addition, in caries-active girls, Alloprevotella species HOT 473 was the only species that exhibited both significant sex differences (4.4-fold difference; p=0.0003) as well as high abundance in numbers (1.85% of the total microbial population). |
| Related Links | https://www.tandfonline.com/doi/pdf/10.1080/20002297.2019.1653124?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720314/pdf |
| ISSN | 20002297 |
| e-ISSN | 20002297 |
| DOI | 10.1080/20002297.2019.1653124 |
| Journal | Journal of Oral Microbiology |
| Issue Number | 1 |
| Volume Number | 11 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2019-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Oral Microbiology Nutrition and Dietetics Salivary Microbiome Sex Differences Dental Caries Children Oral Microbiome |
| Content Type | Text |
| Resource Type | Article |
| Subject | Microbiology (medical) Dentistry Infectious Diseases |
