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Identification and characterization of fully human anti-CD22 monoclonal antibodies
| Content Provider | Scilit |
|---|---|
| Author | Xiao, Xiaodong Ho, Mitchell Zhu, Zhongyu Pastan, Ira Dimitrov, Dimiter S. |
| Copyright Year | 2009 |
| Description | CD22 is a member of the B cell receptor family and is implicated in B cell function and development. It is expressed on multiple forms of B cell lymphoma and is an attractive cancer therapeutic target. We report here the identification of two fully human anti-CD22 antibodies using phage display methodology. Both antibodies exhibit specific binding to cell surface-associated CD22 in multiple B cell lines. Through ELISA using mammalian cell-expressed sub-domains of CD22 as binding antigen, we mapped the binding epitopes of the newly identified CD22 antibodies to be within the Ig-like domains 5 to 7 of CD22. Their epitopes do not overlap with those of several therapeutic antibodies currently in preclinical or clinical development. These antibodies have potential as cancer therapeutic candidates and research reagents. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.4161/mabs.1.3.8113?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726586/pdf |
| Ending Page | 303 |
| Page Count | 7 |
| Starting Page | 297 |
| ISSN | 19420862 |
| e-ISSN | 19420870 |
| DOI | 10.4161/mabs.1.3.8113 |
| Journal | mAbs |
| Issue Number | 3 |
| Volume Number | 1 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2009-05-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Mabs Biochemistry and Molecular Biology Monoclonal Antibody |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
