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Clinical Characteristics and Prognostic Analysis of Gynecologic Cancer with Spinal Metastases: A Single-Center Retrospective Study
| Content Provider | Scilit |
|---|---|
| Author | Liu, Shuzhong Zhou, Xi Song, An Huo, Zhen Yao, Siyuan Wang, Yipeng Liu, Yong Pan, Ling-Ya |
| Copyright Year | 2020 |
| Description | Objective: The purpose of this study is to provide key information on the clinical characteristics, surgical treatment, and potential prognostic factors in patients with metastatic spinal gynecologic cancer (MSGC), with a view to their application in clinical practice. Methods: From January 2010 to January 2020, we performed a retrospective analysis of 14 patients with MSGC who underwent surgical treatment in a single center. Surgical treatment was performed on 14 patients, and a total of 14 operations were performed. The survival time of patients after spinal surgery was analyzed by Kaplan–Meier and Cox regression analysis. Results: The average age of patients was 51.9 years (range 25‒70). The average time from initial surgery to the discovery of spinal metastasis was 60.3 months (2‒180), and the average follow-up time was 19.2 months (2‒55). Spinal tumor progression was found in 9 patients, and 12 patients (85.7%) died during follow-up. In univariate analysis, extraosseous visceral metastasis (p = 0.024), revised Tokuhashi stage (p = 0.025), Tomita stage (p = 0.005), and number of spinal lesions (p = 0.038) were associated with overall survival (OS). Extraosseous visceral metastasis (p = 0.026), revised Tokuhashi stage (p = 0.014), Tomita stage (p = 0.001), and gynecological cancer type (p = 0.039) were associated with progression-free survival. Conclusion: Surgical treatment is an effective treatment for MSGC and relieves pain, restores function and rebuilds stability. Based on our single-center experience, extraosseous visceral metastasis, revised Tokuhashi stage, Tomita stage, and gynecological cancer type may be potential prognostic factors for OS. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445528/pdf https://www.dovepress.com/getfile.php?fileID=60780 |
| Ending Page | 7525 |
| Page Count | 11 |
| Starting Page | 7515 |
| ISSN | 11791322 |
| DOI | 10.2147/cmar.s268075 |
| Journal | Cancer Management and Research |
| Volume Number | 12 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2020-08-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cancer Management and Research Womens Studies Clinical Prognosis Gynecological Cancer Overall Survival Progression-free Survival Spinal Metastasis Surgical Treatment |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology |
