NDLI: Synthesis of Highly Substituted Pyridines via a One-Pot, Three-Component Cascade Reaction of Malononitrile with Aldehydes and S-Alkylisothiouronium Salts in Water

Content Provider	Scilit
Author	Ge, Ze-Mei Li, Run-Tao Wang, Zhong-Qing Cheng, Tie-Ming
Copyright Year	2009
Description	A novel methodology for the synthesis of 2-amino-4-aryl(alkyl)-6-sulfanyl pyridine-3,5-dicarbonitriles via a one-pot, three-component reaction of structurally diversified aldehydes with various S-alkylisothiouronium salts and malononitrile in water has been developed. Utilization of S-alkylisothiouronium salts as thiol equivalents greatly broadens the application of the current method, and also makes the reaction more environmentally friendly.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0029-1217529.pdf
Ending Page	2022
Page Count	3
Starting Page	2020
ISSN	09365214
e-ISSN	14372096
DOI	10.1055/s-0029-1217529
Journal	Synlett
Issue Number	12
Volume Number	2009
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2009-07-01
Access Restriction	Open
Subject Keyword	Organic Chemistry Multicomponent Reactions 2-amino-4-aryl(alkyl)-6-sulfanyl Pyridine-3 S-alkylisothiouronium Salts
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry

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Synthesis of Highly Substituted Pyridines via a One-Pot, Three-Component Cascade Reaction of Malononitrile with Aldehydes and S-Alkylisothiouronium Salts in Water