Electronic Effects on Chiral NHC–Transition-Metal Catalysis

Content Provider	Scilit
Author	Yong, Xuefeng Thurston, Ryan Ho, Chun-Yu
Copyright Year	2019
Description	‡ These authors contributed equally to this work. Though the properties of N-heterocyclic carbenes (NHCs) are generally dominated by the very strong σ donating character, electronic activation has emerged as an effective method to cooperate with typical carbon-framework steric optimization for highly enantioselective chiral NHC–transition-metal catalysis in recent years. NHC electronic changes associated with structural variations are now better understood by quantitative analysis using various methods. Here we highlighted and correlated some interesting chiral induction improvement methods, which were brought by electronic and steric cooperation on chiral NHC–transition-metal catalysis. 1 Introduction 2 Hemilabile Sidechains on NHC Ligands 3 Electronic and Bond Angle Changes Brought by NHC Core Size Variations 4 Electronic Activators on the NHC Core 5 Conjugated Systems and Fused Ring Structures 6 Remote Electronic Activators on the N-Aryl Ring 7 Summary and Outlook
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1611751.pdf
Ending Page	2080
Page Count	23
Starting Page	2058
ISSN	00397881
e-ISSN	1437210X
DOI	10.1055/s-0037-1611751
Journal	Synthesis
Issue Number	10
Volume Number	51
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2019-04-10
Access Restriction	Open
Subject Keyword	Journal: Synthesis Organic Chemistry Electronic Effect Chiral N-heterocyclic Carbenes Transition-metal Catalysis Enantioselective Synthesis
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Catalysis