NDLI: Direct Mannich Reactions: Synthesis of Protected anti-α,β-Diamino Acids

Content Provider	Scilit
Author	Kociok-Köhn, G.
Editor	Cutting, G. A. Stainforth, N. E. John, M. P. Willis, M. C.
Copyright Year	2007
Description	This report describes a direct catalytic Mannich reaction which generates α,α-diamino acids in one step. This is a very important structural motif in many medicinal agents and biologically active compounds. Magnesium perchlorate is the Lewis acid used and the DBFox ligand 1 provides the chiral induction. N-Tosyl imines were chosen as the one reacting partner while isothiocyanate-substituted oxazolidinones were the other nitrogen-containing reactant.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-991353.pdf
Ending Page	1288
Page Count	1
Starting Page	1288
ISSN	18611958
e-ISSN	1861194X
DOI	10.1055/s-2007-991353
Journal	Synfacts
Issue Number	12
Volume Number	2007
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2007-11-22
Access Restriction	Open
Subject Keyword	Journal: Synfacts Organic Chemistry
Content Type	Text
Resource Type	Article

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Direct Mannich Reactions: Synthesis of Protected anti-α,β-Diamino Acids