NDLI: New Macrocyclic Lathyrane Diterpenes, fromEuphorbia lagascae,as Inhibitors of Multidrug Resistance of Tumour Cells

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New Macrocyclic Lathyrane Diterpenes, fromEuphorbia lagascae,as Inhibitors of Multidrug Resistance of Tumour Cells

Content Provider	Scilit
Author	Duarte, Noélia Gyémánt, Nora Abreu, Pedro M. Molnár, Joseph Ferreira, Maria-José U.
Copyright Year	2005
Description	The new macrocyclic lathyrane diterpenes latilagascenes A and B (1 and 2), the diacetylated derivative of 2, latilagascene C (3), and the known diterpenes ent-16α,17-dihydroxyatisan-3-one (4) and ent-16α,17-dihydroxykauran-3-one (5), isolated from the methanol extract of Euphorbia lagascae, were examined for their effects on the reversal of multidrug resistance (MDR) on mouse lymphoma cells. Among the active lathyrane derivatives 1 - 3, compound 2 displayed the highest inhibition of rhodamine 123 efflux of human MDR1 gene transfected mouse lymphoma cells when compared to the untreated cells or the positive control verapamil. The new compounds are the first macrocyclic lathyrane diterpenes showing oxidation at C-16, whose structures were characterized by extensive spectroscopic methods, including 2D NMR experiments $(^{1}H-^{1}$H COSY, HMQC, HMBC and NOESY). The known phenolic compounds vanillic acid (6), p-salicylic acid (7), isofraxidin (8) and cleomiscosin A (9) were also isolated from this species.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2005-873196.pdf
Ending Page	168
Page Count	7
Starting Page	162
ISSN	00320943
e-ISSN	14390221
DOI	10.1055/s-2005-873196
Journal	Planta Medica
Issue Number	2
Volume Number	72
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2005-12-05
Access Restriction	Open
Subject Keyword	Journal: Planta Medica Medicinal Chemistry Euphorbia Lagascae Phenolic Compounds Multidrug Resistance
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Analytical Chemistry Molecular Medicine Pharmacology Complementary and Alternative Medicine Pharmaceutical Science

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