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Oral Contraceptives in Polycystic Ovary Syndrome: Risk-Benefit Assessment
| Content Provider | Scilit |
|---|---|
| Author | Yildiz, Bulent O. |
| Copyright Year | 2008 |
| Description | Combined oral contraceptive pills (OCPs) have been a key component of the chronic treatment of polycystic ovary syndrome (PCOS) by improving androgen excess and regulating menstrual cycles. Earlier epidemiologic studies with second- and third-generation OCPs in the general population have raised important questions regarding long-term cardiometabolic effects of these agents. In PCOS, there are only a few short-term studies with contradictory results evaluating potential adverse effects of OCPs on cardiovascular risk factors and glucose homeostasis. These studies included a small number of participants and did not take into account several confounding factors that might influence the outcome. Nevertheless, limited available data support the benefits of long-term OCP use in PCOS. By contrast, solid evidence for cardiometabolic adverse outcome with the use of these agents, especially with newer OCPs containing antiandrogenic progestins, is lacking. More studies are needed to resolve controversies regarding the safety of long-term OCP use in PCOS. Meanwhile, assessment of each PCOS patient's personal cardiometabolic risk profile should be an essential component of the evaluation before prescribing OCPs and also during follow-up. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-992931.pdf |
| Ending Page | 120 |
| Page Count | 10 |
| Starting Page | 111 |
| ISSN | 15268004 |
| e-ISSN | 15264564 |
| DOI | 10.1055/s-2007-992931 |
| Journal | Seminars in Reproductive Medicine |
| Issue Number | 1 |
| Volume Number | 26 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2008-01-08 |
| Access Restriction | Open |
| Subject Keyword | Journal: Seminars in Reproductive Medicine Endocrinology and Metabolism Keywordsandrogen Excess Oral Contraceptive Cyproterone Acetate |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Physiology (medical) Endocrinology Reproductive Medicine Obstetrics and Gynecology |
