NDLI: One-Pot Synthesis of 2,3-Disubstituted Indoles

Content Provider	Scilit
Author	Lu, B. Zhao, W. Dufour, M. Farina, V. Senanayake, C.
Editor	Wei, H. -X.
Copyright Year	2006
Description	A one-pot regioselective synthesis of 2,3-disubstituted indoles from the reaction of 2-iodoacetanilides with terminal alkynes is described. The reaction, proceeding under Pd-catalysis, involves an initial Sonogashira coupling followed by amidopalladation/reductive elimination (first reported by Cacchi) and proceeds under mild conditions in good yields. The scope of the reaction is inextensively defined: only two $R^{1}$ electron-withdrawing groups and limited alkynes were tested; however, both electron-donating and -withdrawing groups were effective in the Cacchi process.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2006-949421.pdf
Ending Page	1109
Page Count	1
Starting Page	1109
ISSN	18611958
e-ISSN	1861194X
DOI	10.1055/s-2006-949421
Journal	Synfacts
Issue Number	11
Volume Number	2006
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2006-10-24
Access Restriction	Open
Subject Keyword	Journal: Synfacts Organic Chemistry Disubstituted Indoles
Content Type	Text
Resource Type	Article

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