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Value of CT Characteristics in Predicting Invasiveness of Adenocarcinoma Presented as Pulmonary Ground-Glass Nodules
| Content Provider | Scilit |
|---|---|
| Author | Shi, Jingyun Zhou, Xiao Xie, Dong Song, Xiao Yang, Yang Liu, Zhongliu Wang, Haifeng Ding, Hongdou |
| Copyright Year | 2016 |
| Description | Background Less invasive adenocarcinomas (LIAs) of the lung, including adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA), are indications of sublobar resection and has a 5-year disease-free survival rate of almost 100% after surgery. By distinguishing invasive adenocarcinoma from LIA with computed tomography (CT) characteristics, it is possible to determine the extent of resection and prognosis for patients with ground-glass nodules (GGNs) before surgery. Methods We reviewed CT and pathological findings of 728 GGNs in 645 consecutive patients who received curative lung resection in a single center. Only AIS, MIA, and invasive adenocarcinoma were included. Characteristics of CT, including maximum diameter of the lesion (L$ _{max}$) and maximum diameter of the consolidation (C$ _{max}$), were assessed thoroughly. Results Multivariate logistic regression showed that larger L$ _{max}$ (p < 0.001) and nonsmooth margin (p = 0.001) were independent factors for invasive adenocarcinoma in pure GGNs (pGGNs). The optimal cut-off value of L$ _{max}$ was 12.0 mm. In mixed GGNs (mGGNs), multivariate analysis revealed that larger L$ _{max}$ (p < 0.001), larger C$ _{max}$ (p = 0.032), and vacuole sign (p = 0.007) were predictive factors for invasive adenocarcinoma, and the area under curve of regression model was 0.866. The optimal cut-off values of L$ _{max}$ and C$ _{max}$ were 15.4 and 5.8 mm, respectively. No node metastasis was found in 295 patients who had at least three stations of mediastinal lymph nodes dissected. Conclusion In pGGNs, larger L$ _{max}$ (>12.0 mm) and nonsmooth margin were reliable predictors for invasive adenocarcinoma. In mGGNs, lesions with larger L$ _{max}$ (>15.4 mm), larger C$ _{max}$ (>5.8 mm), and vacuole sign were more likely to be invasive adenocarcinoma. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0036-1587592.pdf |
| Ending Page | 141 |
| Page Count | 6 |
| Starting Page | 136 |
| ISSN | 01716425 |
| e-ISSN | 14391902 |
| DOI | 10.1055/s-0036-1587592 |
| Journal | The Thoracic and Cardiovascular Surgeon |
| Issue Number | 02 |
| Volume Number | 65 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2016-08-30 |
| Access Restriction | Open |
| Subject Keyword | Journal: The Thoracic and Cardiovascular Surgeon Respiratory System Computed Tomography Ground-glass Nodules Lung Adenocarcinoma |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine Surgery Cardiology and Cardiovascular Medicine |
