NDLI: Chelating Hydroxyalkyl NHC as Efficient Chiral Ligands for Room-Temperature Copper-Catalyzed Asymmetric Allylic Alkylation

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Chelating Hydroxyalkyl NHC as Efficient Chiral Ligands for Room-Temperature Copper-Catalyzed Asymmetric Allylic Alkylation

Content Provider	Scilit
Author	Crévisy, Christophe Mauduit, Marc Jennequin, Thomas Wencel-Delord, Joanna Rix, Diane Daubignard, Julien
Copyright Year	2010
Description	The application of chiral chelating hydroxy NHC in copper-catalyzed asymmetric allylic alkylation (Cu-AAA) involving various dialkylzincs and allylic phosphate substrates is reported here. From a library of 11 chiral chelating hydroxyalkyl NHC, a fine-tuning has been done to identify the best architectural features enabling to produce the expected γ-adducts in total regioselectivity, good isolated yields, and excellent enantioselectivities (ranging from 93% to >98% ee).
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0029-1220127.pdf
Ending Page	1665
Page Count	5
Starting Page	1661
ISSN	09365214
e-ISSN	14372096
DOI	10.1055/s-0029-1220127
Journal	Synlett
Issue Number	11
Volume Number	2010
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2010-06-01
Access Restriction	Open
Subject Keyword	Journal: Synlett Organic Chemistry Chiral Chelating Diaminocarbene Asymmetric Allylic Alkylation Copper Dialkylzinc
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry

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