NDLI: Diastereocontrol in the Synthesis of 2,3,4-Trisubstituted Pyrrolidines and Tetrahydrofurans via a Palladium(II)-Catalyzed Three-Component Coupling Reaction

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Diastereocontrol in the Synthesis of 2,3,4-Trisubstituted Pyrrolidines and Tetrahydrofurans via a Palladium(II)-Catalyzed Three-Component Coupling Reaction

Content Provider	Scilit
Author	Malinakova, Helena C. Raikar, Sandeep Pal, Benoy Kumar
Copyright Year	2012
Description	The synthesis of trisubstituted pyrrolidines and tetrahydrofurans from boronic acids, allenes, and imines or aldehydes via a five- and a three-step protocol, respectively, is described. The assignment of the relative stereochemistry in the pyrrolidines and tetrahydrofurans confirmed the mechanistically significant stereochemical divergence of the palladium-catalyzed three-component coupling reaction. The methodology is applicable to the preparation of combinatorial libraries of pyrrolidines related to pharmaceutical agents and bioactive natural products.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0031-1290969.pdf
Ending Page	1992
Page Count	10
Starting Page	1983
ISSN	00397881
e-ISSN	1437210X
DOI	10.1055/s-0031-1290969
Journal	Synthesis
Issue Number	13
Volume Number	44
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2012-06-05
Access Restriction	Open
Subject Keyword	Journal: Synthesis Organic Chemistry Stereoselective Synthesis Multicomponent Reactions
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Catalysis

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