NDLI: Metal-Catalyzed Site-Selective Monoacylation of Diols in Aqueous Media

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Metal-Catalyzed Site-Selective Monoacylation of Diols in Aqueous Media

Content Provider	Scilit
Author	Li, Yuyang Kluger∗, Ronald
Copyright Year	2019
Description	Site-selective reactions of water-soluble biomolecules are being developed to produce efficient conversions in water and water/solvent mixtures. This review focuses on the use of designs based on bis-bidentate chelation of large metal ions by diols to be acylated by a co-chelated water-stable reagent. Topics discussed include: 1. The preparation and properties of water-stable acyl phosphate monoesters and their reactions with diol-chelated metal ions. 2. Site-selective monoaminoacylation of 3′-terminal diols of RNA and their applications in protein engineering. 3. Site-selective monoacylation of sugars with acyl phosphate monoesters associated with metal ions, including lanthanum and lead. The combination of metal ion, 1,2-diol, and acyl phosphate monoester produces site-selective reactions in aqueous media that can produce a general approach to site-selective mono-(amino)acylation in RNA and carbohydrates.1 Introduction2 Synthetic Aminoacylation of tRNA3 Activated Amino Acids in Water4 Metal Ions and Their Effects on the Reactivity of Acyl Phosphate Monoesters5 The Challenge of Site-Selective Acylation of Carbohydrates in Water6 Conclusions and Prospects
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1611907.pdf
Ending Page	3791
Page Count	8
Starting Page	3784
ISSN	00397881
e-ISSN	1437210X
DOI	10.1055/s-0037-1611907
Journal	Synthesis
Issue Number	20
Volume Number	51
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2019-08-12
Access Restriction	Open
Subject Keyword	Journal: Synthesis Organic Chemistry Acyl Phosphate Monoesters
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Catalysis

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