Catalytic Asymmetric Aziridination of α,β-Unsaturated Aldehydes

Content Provider	Scilit
Author	Deiana, L. Dziedzic, P. Vesely, J. Ibrahem, I. Rios, R. Sun, J. Córdova, A.
Editor	Zhao, G. -L.
Copyright Year	2011
Description	In this full paper Córdova and coworkers compile their previous results on the catalytic asymmetric aziridination of β- (Angew. Chem. Int. Ed. 2007, 46, 778) and α-substituted (Adv. Synth. Catal. 2010, 352, 3201) α,β-unsaturated aldehydes, respectively. In addition to these results a broadened substrate scope and further functionalizations of the obtained aziridines are presented. Valuable building blocks such as N-protected β-amino esters, β-carboxyl aziridines and N-protected α-hydroxy β-amino acetals were obtained in moderate to good yields and excellent enantioselectivities. Finally proposed mechanisms for the aziridination and the NHC-catalyzed ring-opening-oxidation reactions are discussed.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0030-1260839.pdf
Ending Page	0900
Page Count	1
Starting Page	0900
ISSN	18611958
e-ISSN	1861194X
DOI	10.1055/s-0030-1260839
Journal	Synfacts
Issue Number	08
Volume Number	2011
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2011-07-20
Access Restriction	Open
Subject Keyword	Journal: Synfacts Organic Chemistry Functionalizations
Content Type	Text
Resource Type	Article