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Synthesis of (+)-L-733,060
| Content Provider | Scilit |
|---|---|
| Author | O’Brien, P. Gilday, J. |
| Editor | Bilke, J. L. Moore, S. P. |
| Copyright Year | 2009 |
| Description | (+)-L733,060 is a potent and selective neurokinin-1 substance P antagonist, an important lead for the treatment of Alzheimer’s disease. The key step in this asymmetric synthesis is a refinement of the asymmetric deprotonation of N-Boc pyrrolidine (A) by s-BuLi and (-)-sparteine originally reported by Beak and co-workers (J. Am. Chem. Soc. 1994, 116, 3231). |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0029-1217862.pdf |
| Ending Page | 1069 |
| Page Count | 1 |
| Starting Page | 1069 |
| ISSN | 18611958 |
| e-ISSN | 1861194X |
| DOI | 10.1055/s-0029-1217862 |
| Journal | Synfacts |
| Issue Number | 10 |
| Volume Number | 2009 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2009-09-22 |
| Access Restriction | Open |
| Subject Keyword | Journal: Synfacts Medicinal Chemistry Organic Chemistry Boc Pyrrolidine Key Step Asymmetric Deprotonation Sparteine Originally Originally Reported Important Lead Co Workers |
| Content Type | Text |
| Resource Type | Article |
