NDLI: A Seizure, and Electroencephalographic Signs of a Lowered Seizure Threshold, Associated with Fluvoxamine Treatment of Obsessive-Compulsive Disorder

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A Seizure, and Electroencephalographic Signs of a Lowered Seizure Threshold, Associated with Fluvoxamine Treatment of Obsessive-Compulsive Disorder

Content Provider	Scilit
Author	Trabert, W. Hohagen, F. Winkelmann, G. Berger, M.
Copyright Year	1995
Description	A 38-year-old patient with severe obsessive-compulsive disorder received fluvoxamine in a clinical study. Psychometric ratings showed marked clinical improvement in the third week of fluvoxamine administration, but after 8 weeks, at a dose of 300 mg per day, he suffered a grand mal seizure after drinking a glass of beer (0.2 liter). He had no history of previous epileptic seizures. Careful neurological evaluation including computer tomography and magnetic resonance imaging of the brain revealed no signs of acute disease. EEC before the fit did not show epileptiform activity; after the fit, spikes and spike-wave complexes appeared, which disappeared upon discontinuation of fluvoxamine. Since his obsessive-compulsive symptoms had responded well to fluvoxamine and worsened after its discontinuation, the drug was cautiously reintroduced. Improvement of the obsessive-compulsive symptoms was observed again, but spikes and spike-wave complexes reappeared at a dose of 50 mg per day. Under anticonvulsant treatment with carbamazepine, fluvoxamine was increased to 100 mg per day. No seizures occurred during a follow-up to two years.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-979598.pdf
Ending Page	96
Page Count	2
Starting Page	95
ISSN	01763679
e-ISSN	14390795
DOI	10.1055/s-2007-979598
Journal	Pharmacopsychiatry
Issue Number	03
Volume Number	207
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	1995-05-01
Access Restriction	Open
Subject Keyword	Journal: Pharmacopsychiatry Psychiatry and Mental Health Obsessive Compulsive
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical) Psychiatry and Mental Health

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