NDLI: Sesquiterpenes with Hepatoprotective Activity from Cnidium monnieri on Tacrine-Induced Cytotoxicity in Hep G2 Cells

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Sesquiterpenes with Hepatoprotective Activity from Cnidium monnieri on Tacrine-Induced Cytotoxicity in Hep G2 Cells

Content Provider	Scilit
Author	Oh, Hyuncheol Kim, Jung-Sik Song, Eun-Kyoung Cho, Hyun Kim, Do-Hoon Park, Sung-Eun Lee, Ho-Sub Kim, Youn-Chul
Copyright Year	2002
Description	Bioassay-guided fractionation of the EtOH extract of Cnidium monnieri (Apiaceae) furnished two hepatoprotective sesquiterpenes, torilin (1) and torilolone (2), together with a new derivative, 1-hydroxytorilin (3). Compounds 1 and 2 showed hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The $EC_{50}$ values of compounds 1 and 2 were 20.6 ± 1.86 (P < 0.01) and 3.6 ± 0.1 (P < 0.01) μM, respectively. Silybin as a positive control showed an $EC_{50}$ value of 69.0 ± 3.4 μM.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2002-33796.pdf
Ending Page	749
Page Count	2
Starting Page	748
ISSN	00320943
e-ISSN	14390221
DOI	10.1055/s-2002-33796
Journal	Planta Medica
Issue Number	8
Volume Number	68
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2002-08-01
Access Restriction	Open
Subject Keyword	Journal: Planta Medica Integrative and Complementary Medicine Induced Cytotoxicity
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Analytical Chemistry Molecular Medicine Pharmacology Complementary and Alternative Medicine Pharmaceutical Science

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