NDLI: Synthesis of 1-[2-(Hydroxymethyl)cyclohexyl]pyrimidine Analogues of Nucleosides: A Comparative Study

Content Provider	Scilit
Author	Viña, Dolores Santana, Lourdes Uriarte, Eugenio Quezada, Elías Valencia, Laura
Copyright Year	2004
Description	The synthesis of a new series of 1,2-disubstituted carbonucleosides analogues of pyrimidine (cyclohexane derivatives) is reported. For the synthesis of the uridine analogue 5a, either construction of the base on the amino group of the amino alcohol 3 or on the amido group of the predecessor β-lactam 1 was more efficient than condensation of the base with a protected diol. The cis-configuration of 5a was confirmed by X-ray crystallography. Compound 5a was halogenated with Cl, Br and I at uracil position 5.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2004-831224.pdf
Ending Page	2522
Page Count	6
Starting Page	2517
ISSN	00397881
e-ISSN	1437210X
DOI	10.1055/s-2004-831224
Journal	Synthesis
Issue Number	15
Volume Number	2004
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2004-09-16
Access Restriction	Open
Subject Keyword	Journal: Synthesis Organic Chemistry Mitsunobu Reaction
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Catalysis

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Synthesis of 1-[2-(Hydroxymethyl)cyclohexyl]pyrimidine Analogues of Nucleosides: A Comparative Study