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Synthetic Protocols Mutually Applicable to 4-Oxoquinolines and 4-Oxo-1,8-naphthyridines: Synthesis of 1-Aryl-2-substituted and 1-Aryl-3-fluoro-4-oxoquinolines and 4-Oxo-1,8-naphthyridines
| Content Provider | Scilit |
|---|---|
| Author | Awasaguchi, Ken-Ichiro Hayashi, Hiromi Kawai, Hyouei Tominaga, Hiroko Sato, Yuichiro Hayashi, Kazuya Todo, Yozo |
| Copyright Year | 2012 |
| Description | We have achieved the synthesis of 1-aryl-2-substituted 4-oxoquinoline and 4-oxo-1,8-naphthyridine derivatives, which cannot be synthesized by known methods, via two useful synthons, 2-formyl-4-oxoquinoline and 2-methylsulfonyl-4-oxo-1,8-naphthyridine. We also succeeded in the synthesis of 1-aryl-3-fluoro-4-oxoquinoline by fluorocyclization of N-arylenaminone with $Selectfluor^{®}$ and potassium carbonate in DMF in a one-pot procedure. To the best of our knowledge, this is the first synthesis of 3-fluoro-4-oxoquinoline derivatives. We confirmed that these protocols were mutually applicable to the synthesis of 4-oxoquinoline and 4-oxo-1,8-naphthyridine derivatives. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0031-1290079.pdf |
| Ending Page | 452 |
| Page Count | 5 |
| Starting Page | 448 |
| ISSN | 09365214 |
| e-ISSN | 14372096 |
| DOI | 10.1055/s-0031-1290079 |
| Journal | Synlett |
| Issue Number | 03 |
| Volume Number | 23 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2012-01-03 |
| Access Restriction | Open |
| Subject Keyword | Organic Chemistry Fluorocyclization |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry |
