NDLI: Pharmacological Activation of the GABAergic System Does Not Affect GH and PRL Release in Acromegaly

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Pharmacological Activation of the GABAergic System Does Not Affect GH and PRL Release in Acromegaly

Content Provider	Scilit
Author	Orio, F. Iovino, M. Monteleone, P. Agrusta, M. Steardo, L. Lombardi, G.
Copyright Year	1988
Description	An extensive hypothalamic neurotransmitter impairment has been proposed in acromegaly. However, at the moment, the hypothalamic GABAergic system has been little investigated in this disorder. Since GABA has been shown to modulate growth hormone (GH) and prolactin (PRL) secretion in human subjects, it seemed reasonable to investigate hypothalamic GABAergic functioning through the assessment of basal GH and PRL responses to pharmacological activation of this system. 800 mg of sodium valproate (SV), a drug with GABA facilitating properties, were administered orally to 7 acromegalic patients and 9 healthy volunteers. Blood samples were collected before and after the drug administration for the measurement of plasma GH and PRL levels. SV induced a clear-cut rise in basal GH and a decrease in basal PRL in healthy subjects, but it did not induce any change in the basal levels of these hormones in acromegalics. These results suggest that the response of GH and PRL to SV in acromegaly is qualitatively different from normal controls.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-1010921.pdf
Ending Page	704
Page Count	4
Starting Page	701
ISSN	00185043
e-ISSN	14394286
DOI	10.1055/s-2007-1010921
Journal	Hormone and Metabolic Research
Issue Number	11
Volume Number	20
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	1988-11-01
Access Restriction	Open
Subject Keyword	Journal: Hormone and Metabolic Research Endocrinology and Metabolism Key-words Acromegaly Growth Hormone Sodium Valproate
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Endocrinology, Diabetes and Metabolism Biochemistry Clinical Biochemistry Endocrinology

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