NDLI: Human Growth Hormone Binds to Lactogenic Receptors in Bovine, Ovine and Rat Adrenals

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Human Growth Hormone Binds to Lactogenic Receptors in Bovine, Ovine and Rat Adrenals

Content Provider	Scilit
Author	Ormandy, C. Surus, A. Sutherland, R. Chapman, G.
Editor	Teh, L. -C.
Copyright Year	1988
Description	The distribution of$ ^{125}$I radioactivity in the liver, kidneys, adrenals and serum of male rats was measured 10 minutes after an intravenous bolus of$ ^{125}$I-labelled human growth hormone (hGH) was administered in the presence or absence of a large excess of ovine growth hormone or ovine prolactin. The hGH binding sites in the adrenals had displacement properties characteristic of lactogenic receptors, whereas those in the liver had displacement properties characteristic of somatogenic receptors. Bovine and ovine adrenal microsomal membrane fractions contained high affinity $(K_{a}$ = 1.4-3.3 $nM^{-1}$) binding sites for hGH which showed ligand specificity typical of lactogenic receptors. It is concluded that the hGH binding site in the adrenal gland is a classical lactogenic receptor and that this tissue is a convenient and rich (42.6±6.4 fmol hGH specifically bound/mg protein) source of receptor suitable for further characterization.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-1010815.pdf
Ending Page	281
Page Count	4
Starting Page	278
ISSN	00185043
e-ISSN	14394286
DOI	10.1055/s-2007-1010815
Journal	Hormone and Metabolic Research
Issue Number	05
Volume Number	20
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	1988-05-01
Access Restriction	Open
Subject Keyword	Journal: Hormone and Metabolic Research Endocrinology and Metabolism Key-words Human Growth Hormone Adrenal Gland
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Endocrinology, Diabetes and Metabolism Biochemistry Clinical Biochemistry Endocrinology

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