NDLI: Enantioselective Palladium-Catalyzed Decarboxylative Dearomative Asymmetric Allylic Alkylation of Benzofurans: Diversity-Oriented Synthesis of Flavaglines

Please wait, while we are loading the content...

Enantioselective Palladium-Catalyzed Decarboxylative Dearomative Asymmetric Allylic Alkylation of Benzofurans: Diversity-Oriented Synthesis of Flavaglines

Content Provider	Scilit
Author	Lu ∗, Hai-Hua Cao, Meng-Yue
Copyright Year	2021
Description	With the introduction of new Trost-type bisphosphine ligands bearing a chiral cycloalkane framework, the highly efficient and enantioselective palladium-catalyzed decarboxylative dearomative asymmetric allylic alkylation (AAA) of benzofurans was achieved. This enabled a diversity-oriented synthesis (DOS) of previously unreachable flavaglines, which features two diversification stages. A new avenue for developing flavagline-based drugs was thus established.1 Introduction2 The Dearomative Asymmetric Allylic Alkylation of Benzofurans3 Synthesis of Flavaglines4 Conclusion and Outlook
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1650-4266.pdf
Ending Page	1986
Page Count	6
Starting Page	1981
ISSN	09365214
e-ISSN	14372096
DOI	10.1055/a-1650-4266
Journal	Synlett
Issue Number	20
Volume Number	32
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2021-09-21
Access Restriction	Open
Subject Keyword	Journal: Synlett Palladium Catalysis Dearomative Asymmetric Allylic Alkylation (aaa) Total Synthesis Diversity-oriented Synthesis (dos) N-heterocyclic Carbene (nhc) Catalysis Benzoin Condensation
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in