NDLI: Synthesis of Orthogonally Protected (2R,3R,4S)-4-Amino-2,3-dihydroxyheptane-1,7-dioic Acid

Content Provider	Scilit
Author	Konno, Hiroyuki Tokairin, Yoshinori Maita, Kakeru Takeda, Sho
Copyright Year	2014
Description	(2R,3R,4S)-4-Amino-2,3-dihydroxyheptane-1,7-dioic acid, a common component of cyclic depsipeptide homophymines with anti-HIV activity, was synthesized as its orthogonally protected derivative from Fmoc-Glu(t-Bu)-OH in 6 steps. Osmium-catalyzed dihydroxylation of γ-amino-Z-α,β-unsaturated esters gave the dihydroxy esters with moderate diastereoselectivity. The stereochemistries of the amino acids were determined by comparison of$ ^{1}$H NMR spectra.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0034-1378902.pdf
Ending Page	358
Page Count	8
Starting Page	351
ISSN	00397881
e-ISSN	1437210X
DOI	10.1055/s-0034-1378902
Journal	Synthesis
Issue Number	03
Volume Number	47
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2014-11-06
Access Restriction	Open
Subject Keyword	Journal: Synthesis Organic Chemistry Unusual Amino Acid Dihydroxylation of Z-olefin Glutamic Acid Derivative Cyclic Depsipeptide Jbca Method
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Catalysis

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Synthesis of Orthogonally Protected (2R,3R,4S)-4-Amino-2,3-dihydroxyheptane-1,7-dioic Acid