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Recent Advances in Cross-Couplings of Functionalized Organozinc Reagents
| Content Provider | Scilit |
|---|---|
| Author | Wei, Baosheng Knochel, Paul |
| Copyright Year | 2021 |
| Description | Cross-couplings involving organozinc reagents usually require a Pd-catalyst (Negishi cross-coupling), however, uncatalyzed cross-couplings of zinc organometallics proceed well in the absence of transition-metal catalysts with reactive electrophiles such as benzal 1,1-diacetates, benzhydryl acetates, and iminium trifluoroacetates. Organozinc compounds also undergo C–N bond formation with O-benzoylhydroxylamines or organic azides in the presence of cobalt- or iron-catalysts. Highly diastereoselective and enantioselective cross-couplings can be readily performed with room-temperature configurationally stable alkylzinc species, producing diastereoselectively and enantiomerically enriched products. Finally, highly regioselective magnesiations of functionalized arenes and heteroarenes undergo Negishi (after transmetalation with ZnCl2) or Cu-catalyzed cross-couplings.1 Introduction2 Uncatalyzed Cross-Couplings of Organozinc Reagents with Highly Electrophilic Partners3 Iron- and Cobalt-Catalyzed Aminations using Organozinc Reagents4 Stereo- and Regioselective Cross-Couplings of Organozinc Reagents5 Conclusion |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1589-0150.pdf |
| Ending Page | 254 |
| Page Count | 9 |
| Starting Page | 246 |
| ISSN | 00397881 |
| e-ISSN | 1437210X |
| DOI | 10.1055/a-1589-0150 |
| Journal | Synthesis |
| Issue Number | 02 |
| Volume Number | 54 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2021-08-16 |
| Access Restriction | Open |
| Subject Keyword | Journal: Synthesis Uncatalyzed Cross Couplings Cross Couplings of Organozinc Reagents Diastereoselective |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Catalysis |
