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Diagnostic Accuracy of Triage Tests to Exclude Pulmonary Embolism
| Content Provider | Scilit |
|---|---|
| Author | Lijmer, Jeroen G. Sanson, Bernd-Jan Büller, Harry R. |
| Editor | Brandjes, Dees P. M. Gillavry, Melvin R. Mac |
| Copyright Year | 2001 |
| Description | We performed a study in 403 prospectively included patients with suspected pulmonary embolism to compare the accuracy of a combination of the SimpliRED D-dimer assay and an intuitive clinical probability estimate with either one alone. Based on a conjoint diagnostic reference standard, including ventilation-perfusion lung scintigraphy and pulmonary angiography, the prevalence of pulmonary embolism was 31%. We demonstrated a high sensitivity (98%, 95% CI 95-100) and negative predictive value (94%, 95% CI 79-99) for the combination of the two tests. These figures were more favorable than for either test alone. The specificity of the combination was lower (11%, 95% CI 9-12) and consequently the proportion of patients in whom further diagnostic tests would have been avoided was only 8%. We conclude that the combined use of the SimpliRED test and the clinical probability estimate attains a higher sensitivity than either test alone. However, there remains a risk of false negatives and the exclusion efficiency is limited.$ ^{**}$ The investigators who participated in this study are listed in the appendix. The Dutch Health Insurance Council (project # D094-90) provided financial support for this study. HRB is an established investigator of the Dutch Heart Foundation. |
| Related Links | http://pdfs.semanticscholar.org/09bd/de5ce605ab21c252e4ee7fd6058558e6cf73.pdf http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1615953.pdf |
| Ending Page | 998 |
| Page Count | 4 |
| Starting Page | 995 |
| ISSN | 2567689X |
| DOI | 10.1055/s-0037-1615953 |
| Journal | Thrombosis and Haemostasis |
| Issue Number | 06 |
| Volume Number | 85 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2001-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Thrombosis and Haemostasis Emergency Medicine Respiratory System |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology |
