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Enantioselective Hydroacylation Applied to the Synthesis of Nucleoside Analogues
| Content Provider | Scilit |
|---|---|
| Author | Marcé, P. Díaz, Y. Castillón, S. |
| Editor | Matheu, M. I. |
| Copyright Year | 2008 |
| Description | A short and enantioselective synthesis of carbocyclic nucleosides is reported. The authors opted for a strategy involving an intramolecular rhodium(I)-catalyzed asymmetric hydro-acylation step, which circumvents long reaction sequences previously reported to access carbocyclic intermediates 5 or 7. Both enantiomers of 6 are of interest for their potential antitumor and antiviral activity. Their synthesis is a powerful illustration of enantioselective hydroacylation. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0028-1087406.pdf |
| Ending Page | 0056 |
| Page Count | 1 |
| Starting Page | 0056 |
| ISSN | 18611958 |
| e-ISSN | 1861194X |
| DOI | 10.1055/s-0028-1087406 |
| Journal | Synfacts |
| Issue Number | 01 |
| Volume Number | 2009 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2008-12-18 |
| Access Restriction | Open |
| Subject Keyword | Journal: Synfacts Organic Chemistry |
| Content Type | Text |
| Resource Type | Article |