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Metformin Reverts Deleterious Effects of Advanced Glycation End-Products (AGEs) on Osteoblastic Cells
| Content Provider | Scilit |
|---|---|
| Author | Schurman, L. Sedlinsky, C. Arnol, V. Bruzzone, L. |
| Editor | McCarthy, A. D. Gangoiti, M. V. Cortizo, A. M. |
| Copyright Year | 2008 |
| Description | Advanced glycation endproducts (AGEs) are implicated in the complications of diabetes and ageing, affecting several tissues, including bone. Metformin, an insulin-sensitizer drug, reduces the risk of life-threatening macrovascular complications. We have evaluated the hypothesis that metformin can abrogate AGE-induced deleterious effects in osteoblastic cells in culture. In two osteoblast-like cell lines (UMR106 and MC3T3E1), AGE-modified albumin induced cell death, caspase-3 activity, altered intracellular oxidative stress and inhibited alkaline phosphatase activity. Metformin-treatment of osteoblastic cells prevented these AGE-induced alterations. We also assessed the expression of AGE receptors as a possible mechanism by which metformin could modulate the action of AGEs. AGEs-treatment of osteoblast-like cells enhanced RAGE protein expression, and this up-regulation was prevented in the presence of metformin. Although the precise mechanisms involved in metformin signaling are still elusive, our data implicate the AGE-RAGE interaction in the modulation of growth and differentiation of osteoblastic cells. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-992786.pdf |
| Ending Page | 340 |
| Page Count | 8 |
| Starting Page | 333 |
| ISSN | 09477349 |
| e-ISSN | 14393646 |
| DOI | 10.1055/s-2007-992786 |
| Journal | Experimental and Clinical Endocrinology & Diabetes |
| Issue Number | 06 |
| Volume Number | 116 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2008-02-14 |
| Access Restriction | Open |
| Subject Keyword | Journal: Experimental and Clinical Endocrinology & Diabetes Endocrinology and Metabolism Advanced Glycation End Product Oxidative Stress |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology |
