NDLI: Regioselective Addition of Quinoline Derivatives to Carbonyl Compounds via Palladium-Catalyzed Umpolung with Diethylzinc

Content Provider	Scilit
Author	Matsumoto, Yohei Yamamoto, Kosuke Kuriyama, Masami Nishida, Koyo Onomura, Osamu
Copyright Year	2019
Description	An efficient method for the C-4-selective addition of quinoline derivatives to carbonyl compounds is described. The combination of 2-ethoxy-1-ethoxycarbonyl-1,2-dihydroquinolines (EEDQs) with a palladium catalyst and diethylzinc generates nucleophilic allyl species which undergo addition to various aldehydes and ketones. C-4-Substituted quinoline derivatives are obtained in high to excellent yields with moderate diastereoselectivities.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1610682.pdf
Ending Page	1802
Page Count	8
Starting Page	1795
ISSN	00397881
e-ISSN	1437210X
DOI	10.1055/s-0037-1610682
Journal	Synthesis
Issue Number	08
Volume Number	51
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2019-01-24
Access Restriction	Open
Subject Keyword	Journal: Synthesis Organic Chemistry Palladium Catalysis
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Catalysis

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Regioselective Addition of Quinoline Derivatives to Carbonyl Compounds via Palladium-Catalyzed Umpolung with Diethylzinc