NDLI: Growth Hormone and Carbohydrate Intolerance in Cirrhosis

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Growth Hormone and Carbohydrate Intolerance in Cirrhosis

Content Provider	Scilit
Author	Shankar, Talla P. Jerkins, Terri Bobal, Mary Alice
Editor	Solomon, S. S. Duckworth, W. C. Iyer, R. S.
Copyright Year	1988
Description	Patients with cirrhosis of the liver often have insulin resistance and elevated circulating growth hormone levels. This study was undertaken (a) to evaluate glucose intolerance, insulin resistance and abnormal growth hormone secretion and (b) to determine if GH suppression improves insulin resistance. Glucose tolerance tests (GTT), intravenous insulin tolerance tests (IVITT), arginine stimulation tests (AST) and glucose clamp studies before and during GH suppression with somatostatin were performed in a group of patients with alcohol-induced liver cirrhosis. During GTT cirrhotic subjects had a 2-hour plasma glucose of 200±9.8 ng/dl (N=14) compared to 128±8.0 ng/dl in normal controls (N=15), P < 0.001. Basal GH was elevated in cirrhotic patients and in response to arginine stimulation reached a peak of 17.0±5.4 ng/ml (N=7), compared to a peak of 11.3±1.8 ng/ml in 5 normal controls (P=NS). During IVITT patients with cirrhosis had a glucose nadir of 60.0±4.0 mg/dl (N=9), compared to 29.0±7.0 mg/dl in controls (N=5), P < 0.001. Peak GH levels during IVITT were not significantly different in cirrhotics and controls. Glucose utilization rates in 4 patients with cirrhosis of the liver before somatostatin mediated GH suppression was 3.1±0.5 mg/kg/min and 6.5±1.5 mg/kg/min during somatostatin infusion, P < 0.025. We conclude that patients with alcohol induced cirrhosis have sustained GH elevations resulting in insulin resistance which improves after GH suppression.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-1010889.pdf
Ending Page	583
Page Count	5
Starting Page	579
ISSN	00185043
e-ISSN	14394286
DOI	10.1055/s-2007-1010889
Journal	Hormone and Metabolic Research
Issue Number	09
Volume Number	20
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	1988-09-01
Access Restriction	Open
Subject Keyword	Journal: Hormone and Metabolic Research Endocrinology and Metabolism Key-words Growth Hormone Diabetes Mellitus Glucose Clamp
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Endocrinology, Diabetes and Metabolism Biochemistry Clinical Biochemistry Endocrinology

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