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The adaptive immune system and long-term outcome in patients with stable coronary disease
| Content Provider | Scilit |
|---|---|
| Author | Graf, Senta Nikfardjam, Mariam Lehr, Stephan Maurer, Gerald Wojta, Johann Huber, Kurt Niessner, Alexander |
| Copyright Year | 2005 |
| Description | Summary Components of the adaptive immune system, in particular lymphocytes and immunoglobulin, play a major role in advanced atherosclerotic lesions. We sought to determine whether routine measurements of the relative number of circulating lymphocytes (%L) and γ -globulin (%G) reflecting immunoglobulin are related to event-free survival in patients with stable coronary artery disease (CAD). We prospectively studied the combined endpoint all-cause mortality, myocardial infarction and coronary revascularization procedures in 141 patients after successful percutaneous coronary intervention during a median follow-up time of 13.2 years. Using Cox regression, we found a significant influence of %L on event-free survival (P = 0.007) with a relative risk of 2.21 comparing third to first tertile. Subjects with higher %G values likewise had a shorter event-free survival (P = 0.008) with a relative risk of 1.67 comparing third to first tertile. The predictive value of %L and %G remained significant after adjustment for demographic data, cardiovascular risk factors, extent of CAD and other inflammatory markers. We conclude that the fraction of γ -globulin and in particular the relative lymphocyte cell count may serve as readily available and reliable prognostic tools for the long-term outcome in patients with stable CAD. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1160/TH04-07-0449.pdf |
| Ending Page | 260 |
| Page Count | 4 |
| Starting Page | 257 |
| ISSN | 2567689X |
| DOI | 10.1160/th04-07-0449 |
| Journal | Thrombosis and Haemostasis |
| Issue Number | 02 |
| Volume Number | 93 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2005-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Thrombosis and Haemostasis Cardiology and Cardiovascular Diseases Medical Laboratory Technology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology |
