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Inhibitory Effect of Somatostatin-28 on Pancreatic Polypeptide, Glucagon and Insulin Secretion in Normal Man
| Content Provider | Scilit |
|---|---|
| Author | Marco, J. Correas, I. Zulueta, M. Vincent, E. Coy, D. Comaru-Schally, A. Rodríguez-Arnao, M. Gómez-Pan, A. |
| Copyright Year | 1983 |
| Description | We have compared the effects of equimolar doses of intravenous somatostatin-28 (SS-28) and somatostatin-14 (SS-14) (250 μg and 125 μg, respectively) on the secretion of pancreatic polypeptide (PP), glucagon and insulin evoked by a protein-rich meal in normal subjects. Both peptides reduced the fasting plasma levels of these hormones and completely abolished their responses to the alimentary stimulus; in addition, they caused an early decrease of plasma glucose followed by a hyperglycemic phase. As compared to SS-14, SS-28 elicited a longer-lasting inhibition of PP and insulin secretion and displayed greater hypo- and hyperglycemic effects. A somatostatin-like component, similar to SS-28, has been identified in pancreatic extracts as well as in peripheral plasma. Thus, it might be hypothesized that this peptide plays a role in the control of pancreatic hormone release. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-1018725.pdf |
| Ending Page | 366 |
| Page Count | 4 |
| Starting Page | 363 |
| ISSN | 00185043 |
| e-ISSN | 14394286 |
| DOI | 10.1055/s-2007-1018725 |
| Journal | Hormone and Metabolic Research |
| Issue Number | 08 |
| Volume Number | 15 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 1983-08-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Hormone and Metabolic Research Endocrinology and Metabolism Key-words: Somatostatin-28 Pancreatic Polypeptide |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Endocrinology, Diabetes and Metabolism Biochemistry Clinical Biochemistry Endocrinology |
