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Stereocontrolled Synthesis and Biological Evaluation of Novel Carbocyclic Nucleosides Analogues of Neplanocin F and Abacavir
| Content Provider | Scilit |
|---|---|
| Author | Audran, Gérard Douadi, Ali Brémond, Paul Lanez, Touhami Pannecouque, Christophe |
| Copyright Year | 2010 |
| Description | Starting from a readily available building block, two straightforward diastereoselective approaches to functionalized 3′-methyl-branched carbocyclic nucleoside analogues of neplanocin F and abacavir bearing different purine bases are described. The key steps are a regioselective allylic hydroxylation in the first approach and a ring opening of a cyclic carbonate for the second one, affording allylic alcohols as carbasugar intermediates. In both cases, the carbasugars thus synthesized are then coupled with different purine bases. |
| Related Links | http://pdfs.semanticscholar.org/7355/8754ae7e79e1a849981297733ca45adf7dcd.pdf http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0030-1259100.pdf |
| Ending Page | 115 |
| Page Count | 5 |
| Starting Page | 111 |
| ISSN | 09365214 |
| e-ISSN | 14372096 |
| DOI | 10.1055/s-0030-1259100 |
| Journal | Synlett |
| Issue Number | 01 |
| Volume Number | 2011 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2010-12-10 |
| Access Restriction | Open |
| Subject Keyword | Journal: Synlett Organic Chemistry Stereoselective Synthesis Mitsunobu reaction Carbocyclic Nucleoside |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry |
