NDLI: PREHOSPITAL CORONARY THROMBOLYSIS: A NEW STRATEGY IN ACUTE MYOCARDIAL INFARCTION

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PREHOSPITAL CORONARY THROMBOLYSIS: A NEW STRATEGY IN ACUTE MYOCARDIAL INFARCTION

Content Provider	Scilit
Author	Fine, David G. Applebaum, David Welber, Sima Sapoznikov, Dan Lotan, Chaim Mosseri, Morris Hasin, Yonathan Gotsman, Meryyn S.
Editor	Weiss, A. Teddy
Copyright Year	1987
Description	Thirty-four patients with acute myocardial infarction were treated prospectively using a new strategy of pre-hospital intravenous streptokinase given by a physician-operated mobile intensive care unit. Prehospital treated patients who had experienced no previous myocardial infarction were compared to a similar group treated with streptokinase in-hospital. All patients underwent cardiac catheterization on day 6.Patients receiving streptokinase in the pre-hospital phase of acute myocardial infarction had smaller infarcts and better residual myocardial function than the group given streptokinase in-hospital in terms of peak creatine phosphokinase (900 v.1298 IU, p=0.023), ejection fraction (62 v. 55%, p=0,004), computer-derived dysfunction index (427 v. 727, p=0.003), and electrocardiographic QRS score (4.1 v. 6.4, p=0.001). The only difference between these groups at baseline was the duration of pain prior to initiation of streptokinase therapy (1.0 ± 0.4 hours vs. 1.9 ± 0.9 hours). There were no major complications related to pre-hospital administration of streptokinase.Pre-hospital stretokinase infusion is feasible, safe and practical. It reduces ischemia time because treatment is not delayed until hospital arrival and therapy limits infarct size. Thrombolytic therapy for acute myocardial infarction can be initiated at home and should not be limited to hospitalized patients.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0038-1642979.pdf
DOI	10.1055/s-0038-1642979
Issue Number	01
Volume Number	58
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	1987-07-01
Access Restriction	Open
Subject Keyword	Peripheral Vascular Disease Acute Myocardial Infarction
Content Type	Text
Resource Type	Article

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